Advanced Pharmacology - I

THEORY 1.

General Pharmacology a.

Pharmacokinetics: The dynamics of drug absorption, distribution, biotransformation and elimination. Concepts of linear and non-linear compartment models.

Significance of Protein binding.

b. Pharmacodynamics:

Mechanism of drug action and the relationship between drug concentration and effect. Receptors, structural and functional families of receptors, quantitation of drug receptors interaction and elicited effects.

Hrs Neurotransmission a. General aspects and steps involved in neurotransmission.

b. Neurohumoral transmission in autonomic nervous system (Detailed study about neurotransmitters- Adrenaline and Acetyl choline).

c. Neurohumoral transmission in central nervous system (Detailed study about neurotransmitters- histamine, serotonin, dopamine, GABA, glutamate and glycine].

d. Non adrenergic non cholinergic transmission (NANC). Co- transmission Hrs Systemic Pharmacology A detailed study on pathophysiology of diseases, mechanism of action, pharmacology and toxicology of existing as well as novel drugs used in the following systems Autonomic Pharmacology Parasympathomimetics and lytics, sympathomimetics and lytics, agents affecting neuromuscular junction Central nervous system Pharmacology General and local anesthetics Sedatives and hypnotics, drugs used to treat anxiety.

Depression, psychosis, mania, epilepsy, neurodegenerative diseases.

Narcotic and non-narcotic analgesics.

Hrs Cardiovascular Pharmacology Diuretics, antihypertensives, antiischemics, anti- arrhythmics, drugs for heart failure and hyperlipidemia.

Hematinics, coagulants , anticoagulants, fibrinolytics and anti- platelet drugs Hrs Autocoid Pharmacology The physiological and pathological role of Histamine, Serotonin, Kinins Prostaglandins Opioid autocoids.

Pharmacology of antihistamines, 5HT antagonists.

Hrs REFEERENCES

1. The Pharmacological Basis of Therapeutics, Goodman and Gillman‘s

2. Principles of Pharmacology. The Pathophysiologic basis of drug Therapy by David E Golan, Armen H, Tashjian Jr, Ehrin J,Armstrong, April W, Armstrong, Wolters, Kluwer-Lippincott Williams & Wilkins Publishers.

3. Basic and Clinical Pharmacology by B.G Katzung

4. Hand book of Clinical Pharmacokinetics by Gibaldi and Prescott.

5. Applied biopharmaceutics and Pharmacokinetics by Leon Shargel and Andrew B.C.Yu.

6. Graham Smith. Oxford textbook of Clinical Pharmacology.

7. Avery Drug Treatment

8. Dipiro Pharmacology, Pathophysiological approach.

9. Green Pathophysiology for Pharmacists.

10. Robbins & Cortan Pathologic Basis of Disease, th Ed.

(Robbins Pathology)

11. A Complete Textbook of Medical Pharmacology by Dr. S.K Srivastava published by APC Avichal Publishing Company

12. KD.Tripathi. Essentials of Medical Pharmacology.

13. Modern Pharmacology with Clinical Applications, Craig Charles R. & Stitzel Robert E., Lippincott Publishers.

14. Clinical Pharmacokinetics & Pharmacodynamics :

Concepts and Applications – Malcolm Rowland and Thomas N.Tozer, Wolters Kluwer, Lippincott Williams & Wilkins Publishers.

15. Applied biopharmaceutics and Pharmacokinetics, Pharmacodynamics and Drug metabolism for industrial scientists.

16. Modern Pharmacology, Craig CR. & Stitzel RE, Little Brown & Company.