Chemistry of Natural Products

THEORY 1.

Study of Natural products as leads for new pharmaceuticals for the following class of drugs a) Drugs Affecting the Central Nervous System:

Morphine Alkaloids b) Anticancer Drugs: Paclitaxel and Docetaxel, Etoposide, and Teniposide c) Cardiovascular Drugs: Lovastatin, Teprotide and Dicoumarol d) Neuromuscular Blocking Drugs: Curare alkaloids e) Anti-malarial drugs and Analogues f) Chemistry of macrolid antibiotics (Erythromycin, Azithromycin, Roxithromycin, and Clarithromycin) and β - Lactam antibiotics (Cephalosporins and Carbapenem) a) Alkaloids General introduction, classification, isolation, purification, molecular modification and biological activity of alkaloids, general methods of structural determination of alkaloids, structural elucidation and stereochemistry of ephedrine, morphine, ergot, emetine and reserpine.

Hrs Hrs b) Flavonoids Introduction, isolation and purification of flavonoids, General methods of structural determination of flavonoids; Structural elucidation of quercetin.

c) Steroids General introduction, chemistry of sterols, sapogenin and cardiac glycosides.

Stereochemistry and nomenclature of steroids, chemistry of contraceptive agents male & female sex hormones (Testosterone, Estradiol, Progesterone), adrenocorticoids (Cortisone), contraceptive agents and steroids (Vit – D).

a) Terpenoids Classification, isolation, isoprene rule and general methods of structural elucidation of Terpenoids; Structural elucidation of drugs belonging to mono (citral, menthol, camphor), di(retinol, Phytol, taxol) and tri terpenoids (Squalene,Ginsenoside) carotinoids (β carotene).

b) Vitamins Chemistry and Physiological significance of Vitamin A, B1, B2, B12, C, E, Folic acid and Niacin.

Hrs a). Recombinant DNA technology and drug discovery rDNA technology, hybridoma technology, New pharmaceuticals derived from biotechnology; Oligonucleotide therapy.

Gene therapy: Introduction, Clinical application and recent advances in gene therapy, principles of RNA & DNA estimation b).

Active constituent of certain crude drugs used in Indigenous system Diabetic therapy – Gymnema sylvestre, Salacia reticulate, Pterocarpus marsupiam, Swertia chirata, Trigonella foenum graccum; Liver dysfunction – Phyllanthus niruri; Antitumor – Curcuma longa Linn.

Hrs Structural Characterization of natural compounds Structural characterization of natural compounds using IR, 1HNMR, 13CNMR and MS Spectroscopy of specific drugs e.g., Penicillin, Morphine, Camphor, Vit-D, Quercetin and Digitalis glycosides.

Hrs